產(chǎn)品詳情介紹
轉(zhuǎn)化生長(zhǎng)因子-beta1（TGF-beta1/TGFB1）是一種多功能細(xì)胞因子，與其受體具有很強(qiáng)的結(jié)合能力[1]。不同物種的TGF-beta1蛋白的氨基酸序列非常保守。TGF-beta1蛋白前體無(wú)活性，激活的TGF-beta1蛋白與普遍表達(dá)的細(xì)胞表面 TGF-beta1型受體 (TGFBRI) 和 II 型受體 (TGFBRII) 結(jié)合[2]。TGF-beta1蛋白可以調(diào)節(jié)細(xì)胞增殖、生長(zhǎng)、分化和細(xì)胞運(yùn)動(dòng)，并具有免疫調(diào)節(jié)和促纖維化作用[3-4]。
[1] Chambaz E M, Souchelnitskiy S, Pellerin S, et al. Transforming Growth Factor-βs: A Multifunctional Cytokine Family: Implication in the Regulation of Adrenocortical Cell Endocrine Functions. Hormones, 1996, 45(3-5): 222-226.
[2] Maroni D, Davis JS. TGFB1 disrupts the angiogenic potential of microvascular endothelial cells of the corpus luteum. J Cell Sci, 2011, 124(14):2501-2510.
[3] Rustenhoven J, Aalderink M, et al. TGF-beta1 regulates human brain pericyte inflammatory processes involved in neuro vasculature function. J Neuro inflammation. 2016, 13:37.
[4] Zhang K, Yang C, Chang L, et al. Essential role of microglial transforming growth factor-β1 in antidepressant actions of (R)-ketamine and the novel antidepressant TGF-β1. Trans Psychiatry. 2020, 10(1):32.
