產(chǎn)品詳情介紹
CD166又稱為活化白細(xì)胞細(xì)胞粘附分子（ALCAM），是免疫球蛋白超家族的成員，在胞外區(qū)有五個免疫球蛋白樣結(jié)構(gòu)域（VVC2C2C2）[1]。它在臍血造血干細(xì)胞、淋巴管內(nèi)皮細(xì)胞、皮膚、扁桃體、外周血單核細(xì)胞、單核細(xì)胞衍生的樹突狀細(xì)胞上均有表達(dá)[2-5]。另外，CD166通過與T細(xì)胞表面糖蛋白CD6的相互作用促進(jìn)T細(xì)胞的活化與增殖[4,5]。本產(chǎn)品為小鼠抗人CD166單克隆抗體，用于FC方法特異性檢測人CD166蛋白。
CD系列產(chǎn)品介紹視頻
[1] Bowen MA, Patel DD, Li X, et al. Cloning, Mapping, and Characterization of Activated Leukocyte-Cell Adhesion Molecule (ALCAM), a CD6 Ligand [J]. J Exp Med. 1995, 181: 2213-20.
[2] Chitteti B R, Kobayashi M, Cheng Y, et al. CD166 regulates human and murine hematopoietic stem cells and the hematopoietic niche [J]. Blood. 2014, 124(4): 519-29.
[3] Iolyeva M, Karaman S, Willrodt AH, et al. Novel role for ALCAM in lymphatic network formation and function [J]. FASEB J. 2013, 27(3): 978-90.
[4] Hassan NJ, Barclay AN, Brown MH. Frontline: Optimal T cell activation requires the engagement of CD6 and CD166 [J]. Eur J Immunol. 2004, 34(4): 930-40.
[5] Zimmerman AW, Joosten B, Torensma R, et al. Long-term engagement of CD6 and ALCAM is essential for T-cell proliferation induced by dendritic cells [J]. Blood. 2006, 107(8): 3212-20.
